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Updated: May 10, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model
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基于结构的设计,一种免疫原性,形状稳定的FimH抗原用于尿路感染疫苗

Natalie C Silmon de Monerri1, Ye Che2, Joshua A Lees2

  • 1Vaccine Research and Development, Pfizer Inc, Pearl River, New York, New York, United States of America.

PLoS pathogens
|February 19, 2025
PubMed
概括

开发了一种新的哺乳动物细胞生产方法和FimH蛋白的计算设计,产生了针对尿路感染 (UTI) 的有效疫苗候选者. 这种改进的FimH变种阻断了细菌粘附,并引起了保护性抗体,推动了尿路感染疫苗的开发.

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