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Updated: May 27, 2025

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内抗原呈现细胞通过纳米纤维激活同时发生的三级淋巴体结构de novo新生代

Ran Cheng1, Sucheng Li1, Xianbin Ma2

  • 1School of Life Science, Beijing Institute of Technology, Beijing 100081, P.R. China.

Science advances
|February 19, 2025
PubMed
概括

研究人员开发了一种新的仿生纳米纤维,用于诱导瘤中的三级淋巴体结构 (TLS). 这种方法激活免疫细胞,促进适应性免疫反应,防止瘤生长,特别是在免疫冷瘤中.

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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