喉电刺激有利地改变健康人体的喉食道功能:一个使用高分辨率人计阻抗的随机试验
Marthe Everaert1, Shaheen Hamdy2, Ann Goeleven1,3
1Department of Neurosciences, Deglutology, Research group Experimental Otorhinolaryngology (ExpORL), University of Leuven (KU Leuven), Leuven, Belgium.
Journal of applied physiology (Bethesda, Md. : 1985)
|February 19, 2025
概括
喉电刺激 (PES) 通过增强喉和食道指标,在健康个体中暂时改善吞功能. 这些通过高分辨率人测阻抗测量的好处是短暂的,效果在24小时后会减弱.
科学领域:
- 生理学 生理学 生理学
- 胃肠病学 胃肠病学
- 神经学 神经学
背景情况:
- 喉电刺激 (PES) 显示出临床前景,可改善乱症患者的吞能力.
- PES影响吞功能的具体生理机制,特别是在健康个体中,仍然不清楚.
- 喉解剖学的变化需要标准化的电极放置,以获得有效的PES.
研究的目的:
- 评估PES对正常吞生理学的急性影响,使用高分辨率测量阻抗 (HRMI).
- 评估喉长度变异对PES电极放置的影响.
- 为了确定PES引起的吞功能变化的持续时间.
主要方法:
- 一项前性随机对照试验 (RCT) 涉及20名无症状志愿者.
- 参与者接受了PES或SHAM治疗3天.
- 压力流量分析 (PFA) 的HRMI用于测量在基线,1-2小时和治疗后24-72小时的吞功能. 用于标准化导管放置,测量了喉长度.
主要成果:
- 与SHAM组相比,PES组在多种喉和食道指标中显著改善,导致治疗后1-2小时全身吞功能得到改善 (P = 0.029).
- 在治疗后24-72小时内,对吞功能的有益影响基本上不存在.
- 在大多数志愿者中,由于喉长度的变化,需要调整电极放置 (1-3厘米).
结论:
- 在健康个体中,PES可以暂时增强吞功能和生理储备.
- 观察到的喉收缩能力的改善,上食道关节的放松和玻尿酸的流动是暂时的.
- 基于喉长度测量的标准化电极放置对于PES的有效性至关重要.
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