难以负担药品和慢性阻塞性肺部疾病的结果之间的关联
Sonal G Mallya1, Alka Upadhyay2, Kevin J Psoter3
1Johns Hopkins Medicine, Pulmonary and Critical Care Medicine, Baltimore, Maryland, United States; smallya1@jhmi.edu.
难以购买慢性阻塞性肺病 (COPD) 药物与更糟糕的健康状况和较低的坚持有关. 解决药物费用可能会改善COPD管理和患者福祉.
科学领域:
- 肺部医学 肺部医学
- 卫生经济学 卫生经济学
- 健康的社会决定因素
背景情况:
- 吸入式支气管扩展剂对于治疗慢性阻塞性肺病 (COPD) 至关重要.
- 药物费用代表了COPD患者的大量自费开支.
- 药物负担能力和COPD的临床结果之间的关系仍未得到充分研究.
研究的目的:
- 调查药物负担能力困难与COPD相关的发病率之间的关联.
- 检查药物负担能力挑战对心理健康的影响.
- 评估COPD患者的药物费用和药物坚持之间的关系.
主要方法:
- 该研究对249名被诊断患有COPD的个人进行了12个月的跟踪.
- 每六个月评估一次患者报告的结果,心理健康和药物坚持.
- 多变量和固定效应回归模型分析了药物负担能力和随时间的结果之间的关联.
主要成果:
- 虽然基线上难以负担药品的困难与12个月的结果没有关联,但随着时间的推移变化是显著的.
- 增加负担药物的困难与更糟糕的COPD健康状况相关,呼吸障碍增加,生活质量降低.
- 负担能力的变化与更高的焦虑和抑郁症状和更低的药物坚持有关,但并没有恶化.
结论:
- 负担慢性肺炎药物能力的变化与增加的呼吸道发病率,心理困扰和降低药物坚持有关.
- 药物成本是COPD患者健康的重要,潜在的可修改的社会决定因素.
- 针对药物的负担能力可能会改善COPD患者的健康状况和治疗坚持.
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