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Updated: Jul 11, 2026

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尼克洛萨米德作为p300/转录因子蛋白质-蛋白质相互作用抑制剂的发现

Dhina Fitriastuti1, Kazuki Miura2, Satoshi Okada2

  • 1School of Life Science and Technology, Institute of Science Tokyo, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.

Bioorganic & medicinal chemistry
|February 19, 2025
PubMed
概括

尼克洛萨米德抑制缺氧诱导因子1α (HIF-1α) /p300蛋白质-蛋白质相互作用 (PPI),提供了一个新的治疗策略. 这种化合物还针对其他p300相互作用,影响基因表达.

关键词:
基因素乙烯转移酶 p300 的基因组.尼克洛萨米德 (Niclosamide) 是一种尼克洛萨米德.蛋白质蛋白质相互作用蛋白蛋白相互作用抑制剂.选试验系统的选试验系统

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Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a DNA...