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Updated: Jun 15, 2026

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke
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通过细胞外基质水凝对抗免疫抑制,以促进脑组织重塑和创伤性脑损伤后神经功能恢复

Bixue Wang1, Qiya Zhang1, Changsheng Liu1

  • 1Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, PR China.

Biomaterials
|February 19, 2025
PubMed
概括

一种新的水凝生物材料通过恢复免疫功能和促进脑细胞再生,有效治疗创伤性脑损伤 (TBI). 这种创新方法增强了TBI患者的神经发生和神经恢复.

关键词:
中枢神经系统的损伤.氨酸是什么? 氨酸是什么?免疫抑制是一种免疫抑制.神经新生是神经发生的过程.神经元再生的神经元再生流体细胞衍生的因子因子

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Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...
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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...