简要报告:将种族排除在感染艾滋病毒或没有感染艾滋病毒的人群肺功能解释中的影响
Richard J Wang1, Ken M Kunisaki2,3, Alison Morris4
1Department of Medicine, University of California San Francisco, San Francisco, CA.
Journal of acquired immune deficiency syndromes (1999)
|February 19, 2025
概括
从肺功能测试中删除种族可能更好地识别艾滋病毒感染者的肺功能障碍. 对一氧化碳 (DLCO) 扩散能力的种族中立方法显示,它可以更好地预测男性的呼吸系统健康状况.
科学领域:
- 肺部医学 肺部医学
- 艾滋病毒研究 艾滋病毒研究
- 健康 公平 卫生 公平
背景情况:
- 特定于种族的肺功能参考方程可能会掩盖呼吸系统健康方面的种族差异.
- 从肺功能解释中删除种族对艾滋病毒分析的影响尚不清楚.
研究的目的:
- 调查种族特异性与种族中立性肺功能参考方程对艾滋病毒和肺功能之间的关联的影响.
- 为了比较种族特异和种族中立方法对呼吸系统健康相关生活质量的预测性表现.
主要方法:
- 从多中心艾滋病队列研究和妇女机构间艾滋病毒研究的艾滋病毒阳性和艾滋病毒阴性参与者的肺功能测量 (呼吸量测量,DLCO) 的分析.
- 使用特定种族 (NHANES) 和种族中立 (GLI) 参考方程生成预测值的百分比.
- 回归模型来评估艾滋病毒与肺功能之间的关联;阿尔佩丁的F测试用于预测性比较.
主要成果:
- 与没有艾滋病毒的人相比,艾滋病毒感染者显示出明显较低的百分比预测DLCO,无论方程类型如何.
- 在艾滋病毒阳性和艾滋病毒阴性个体之间没有发现螺旋计测量的显著差异.
- 种族中立的DLCO对呼吸系统生活质量的预测在男性中更好,但在女性中没有.
结论:
- 种族中立的肺功能参考方程有效地识别了艾滋病毒感染或感染艾滋病毒风险的个体的肺功能障碍.
- 对于DLCO,种族中立的方法在检测临床显著损害方面可能比种族特定的方程更有效.
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