基于单个标记物,分子对接和多变量统计数据的多元组件定量分析的Shenqi Tongmai口服液质量控制
Qian Li1,2, Li Wang1,2, Liuping Tan1
1Department of Pharmacy, Liuzhou Hospital of Traditional Chinese Medicine, Liuzhou, China.
Phytochemical analysis : PCA
|February 19, 2025
概括
通过确定九个成分及其抗氧化活性来评估Shenqi Tongmai口服液 (SQTM) 的质量. 罗斯玛林酸,黄素和原甲被确定为这种心血管治疗的关键质量标记.
科学领域:
- 传统中国医药 传统中国医药
- 药理学 药理学是指药理学的学科.
- 分析化学 分析化学
背景情况:
- 沈通迈口服液 (SQTM) 是一种广泛用于治疗心血管疾病的中国传统医药.
- 目前,SQTM缺乏标准化的质量评估系统,这阻碍了治疗结果的一致性.
- 本研究解决了对SQTM强有力的质量控制框架的需求.
研究的目的:
- 建立SQTM中九个关键组件的定量分析方法.
- 确定可靠的质量控制指标 (Q-Markers) 用于全面的SQTM质量评估.
- 为了将化学成分与抗氧化活性相关联,以了解SQTM的治疗机制.
主要方法:
- 通过单个标志物 (QAMS) 对多组分的定量分析用于确定9种活性化合物.
- 用DPPH和基清除试验来评估抗氧化能力.
- 应用了多变量统计分析,包括灰色关系分析 (GRA),双变量关联分析 (BCA) 和部分最小平方回归 (PLSR).
- 分子对接和体外实验验证实了个体化合物的抗氧化活性.
主要成果:
- 该QAMS方法的准确性与外部标准方法的准确性相美.
- 罗斯玛林酸,醇和原甲被确定为SQTM抗氧化活性的重要贡献者.
- 这些已识别的化合物被证实是关键的药学动力学成分和潜在的Q标记物.
结论:
- 该研究成功地确定了Shenqi Tongmai口服液的关键质量标志物 (Q-标志物).
- 建立了SQTM质量控制的综合分析方法.
- 这项研究为提高SQTM的质量控制和治疗标准化提供了基础.
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