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短暂戒断的成大脑:互联网游戏障碍和烟草使用障碍之间的功能连接模式的相似性和差异
Xuefeng Xu1, Bo Yang1, Yanbin Zheng1
1Department of Psychology, Yunnan Normal University, Kunming, Yunnan Province, China.
Progress in neuro-psychopharmacology & biological psychiatry
|February 19, 2025
概括
互联网游戏障碍 (IGD) 和烟草使用障碍 (TUD) 在戒断期间显示出类似的大脑活动变化. 然而,功能性连接性不同,IGD显示连接性增加,TUD显示连接性下降,为成机制提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 成研究 研究成研究
- 精神病学是一个精神病学.
背景情况:
- 互联网游戏障碍 (IGD) 得到越来越多的认可,但其神经支和将其归类为成仍然存在争议.
- 之前的研究中不一致的发现可能源于参与者渴望水平的变化.
- 禁欲期间的大脑活动与中性状态不同,需要对禁欲IGD个体进行研究.
研究的目的:
- 通过比较短暂戒断期间的大脑活动与烟草使用障碍 (TUD) 和健康对照来研究互联网游戏障碍 (IGD) 的神经基础.
- 通过静止状态功能磁共振成像 (fMRI) 识别IGD和TUD之间大脑功能的相似性和差异.
- 探索大脑活动模式在分类成个体中的潜力.
主要方法:
- 招募了三组:61名IGD患者,61名TUD患者和80名健康对照人群 (全部男性).
- 在约1.5小时的戒断后收集了静止状态fMRI数据.
- 分析了低频波动 (ALFF) 和功能连接 (FC) 的幅度,并使用神经网络分析进行分类.
主要成果:
- 无论是IGD还是TUD组,都在包括上额回,轨道前额皮质,前中心回,尾状回和乳头等区域表现出改变的ALFF.
- 功能连接分析显示,IGD和TUD之间在轨道前部区域存在相似之处,但在执行控制和奖励途径方面存在差异.
- 一个神经网络模型有效地根据异常的ALFF大脑区域从健康对照组分类成个体.
结论:
- 患有IGD和TUD的个体在短暂的戒断期间表现出可比的ALFF变化.
- 功能连接模式有所不同,IGD显示连接性增加,TUD显示连接性减少.
- 这些神经差异可能反映了与物质使用障碍相比,IGD的独特渴望机制,增强了我们对IGD神经基础的理解.
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