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3D打印个性化口服分解药片,具有复杂结构,用于治疗特殊人群

Zhiqiang Tang¹, Xuejun Chen¹, Xiaoxuan Hong²

¹College of Pharmacy, Yanbian University, Yanji 133002, China; Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

International journal of pharmaceutics

|February 19, 2025

概括

3D打印技术创造了个性化的口腔分解平板电脑 (ODT),具有像盲文和QR码这样的独特功能. 这项创新为有特殊需求的个人提供量身定制的药物治疗解决方案,提高药物安全性和药物坚持性.

科学领域:

制药科学制药科学
生物材料工程生物材料工程
添加剂制造添加剂制造添加剂制造

背景情况:

个性化药物治疗对特殊人群 (儿童,老年人,视力受损者) 面临挑战,原因是独特的药物需求.
3D打印提供了一种创新的方法,用于创建具有复杂设计的个性化药物产品,提高药物安全性和药物坚持性.

研究的目的:

利用粘合剂喷射3D打印 (BJ-3DP) 来制造具有个性化剂量和复杂结构的乙氨基口服分解片 (ODT).
评估将患者特定功能 (如盲文,QR码和定制设计) 纳入ODT的可行性.

主要方法:

粘合剂喷射3D打印 (BJ-3DP) 用于制造乙氨基ODT.
粉末和油墨配方的可打印性被评估.
ODT的设计有个性化剂量,嵌入式QR码,卡通人物,文本和升高的盲文.
内部结构被设计为一种松散的粉末形式的非喷射油墨空间.

主要成果:

评估了粉末和油墨配方的可打印性能.
对ODT的特征包括多孔性,表面粗性,微型CT扫描,机械性质和体外药物释放.
成功制造了具有个性化剂量和复杂表面/内部结构的ODT.

结论:

通过BJ-3DP制造的复杂结构的个性化ODT显示出针对特定患者群体量身定制的治疗解决方案的潜力.
这项技术可以显著提高有特殊需求的个人的药物安全性和药物坚持.

关键词:

粘合剂喷射 3D打印 3D打印复杂的结构复杂的结构.口服可分解片,可消化片特殊种群的特殊种群.治疗解决方案治疗解决方案

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