身体活动与糖尿病之间的关联:在一个横截面的NHANES研究中,对涉及系统性免疫炎症指数的调解分析
Yongze Chen1,2, Ruixian Huang1, Zhenhua Mai1
1Department of Epidemiology and Medical Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, China.
BMJ open
|February 19, 2025
概括
定期体育活动 (PA) 与糖尿病 (DM) 的风险降低有关. 系统性免疫炎症指数 (SII) 在这种关系中起着调解作用,突出显示炎症.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 糖尿病 (DM) 是一个重要的全球健康问题.
- 身体活动 (PA) 被认为是对DM的保护因素.
- 炎症标志物如系统性免疫炎症指数 (SII) 在PA-DM关系中的作用需要进一步阐明.
研究的目的:
- 调查身体活动 (PA) 和糖尿病 (DM) 之间的关联.
- 检查系统性免疫-炎症指数 (SII) 对PA-DM关系的调解作用.
- 为针对DM预防的公共卫生战略提供证据.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (2005-2018) 进行的横截面研究.
- 包括9493名20岁及以上的美国成年人.
- 通过自我管理问卷 (代谢等效得分) 评估PA,并使用标准公式计算SII (SII=血小板×中性粒/淋巴细胞).
主要成果:
- 总共分析了9493名参与者,其中1672人被诊断为DM.
- 患有DM的参与者表现出较低的PA水平和较高的SII.
- 较高的PA显着与DM风险降低相关;SII调解了PA和DM之间的关系 (调解比例从3.12%到12.141%不等).
结论:
- 强有力的证据支持身体活动与糖尿病风险之间的反向关联.
- 系统性免疫炎症指数 (SII) 在很大程度上调解了PA和DM之间的关系.
- 这些发现强调了PA和管理炎症对DM预防和控制的重要性.
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