使用替代案例定义估计室外温度和急性损伤之间的关联
Benjamin Rabin1, Rohan D'Souza, E Jennifer Weil
1From the School of Medicine, Emory University, Atlanta, Georgia (B.R.); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia (B.R.); Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia (R.D'S., H.H.C.); Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia (E.J.W.); and Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia (S.E., N.S.).
高环境热量暴露与急性损伤 (AKI) 有关,即使在未被诊断的情况下也是如此. 这项研究强调了识别热量的重要性.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學.
- 流行病学 流行病学
背景情况:
- 急性损伤 (AKI) 是一个重要的临床问题.
- 暴露于环境热量是AKI的潜在环境风险因素.
- 由于诊断的可变性,准确估计热量和AKI之间的关联是具有挑战性的.
研究的目的:
- 改进环境热暴露和社区获得的AKI之间的关联的估计.
- 改善AKI与热暴露有关的病例确定.
- 为了比较不同的案例定义来识别与热有关的研究中的AKI.
主要方法:
- 采用了一个案例交叉研究设计.
- 分析了亚特兰大与AKI相关的急诊室访问的数据.
- 来自Daymet的气象数据被用来评估热量暴露.
- 我们比较了七种不同的AKI案例定义.
主要成果:
- 在所有案例定义中观察到较高温度和AKI之间的积极关联.
- 在ICD编码的AKI作为主要诊断的病例中发现了最强的关联 (OR,1.15;95% CI,1.01-1.31).
- 在使用实验室结果诊断的,但缺乏ICD编码的AKI诊断的病例中,也发现了显著的热相关性.
结论:
- 相当多的AKI病例仍未被诊断出来.
- 这些未被诊断的AKI病例与暴露于环境热量有显著的关联.
- 这些发现强调了热量对脏健康的公共卫生影响,以及需要改进诊断策略的必要性.
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