精神分裂症谱系障碍的中国住院患者的心血管并发症
Zhe Dong1, Gang Wu2, Hongbing Liu3
1Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China.
Schizophrenia (Heidelberg, Germany)
|February 19, 2025
概括
精神分裂症谱系障碍 (SSD) 中的心血管疾病 (CVD) 显示出不同的模式,包括高血压和心力衰竭. 男性性别和特定的抗精神病药物与这些患者心血管疾病风险更高有关.
科学领域:
- 精神病学是一个精神病学.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 是精神分裂症谱系障碍 (SSD) 患者过早死亡的主要原因.
- 了解SSD患者的心血管疾病并发症模式对于有针对性的干预至关重要.
- 之前的研究还没有充分详细说明这些并发症模式.
研究的目的:
- 为了确定SSD的住院患者中CVD并发症的独特模式.
- 调查与这些已识别的心血管疾病并发症模式相关的因素.
主要方法:
- 隐性类分析 (LCA) 用于识别来自2830名中国住院患者 (2015-2023) 电子病历 (EMR) 的并发病模式.
- 多项逻辑分析评估了各种因素对这些模式的影响,计算了几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 确定了四种不同的心血管疾病并发症模式:低风险心血管疾病 (47.86%),初级高血压 (30.15%),心力衰竭 (12.99%),心脏门和血管疾病 (8.99%).
- 与低风险组相比,男性患者患初级高血压 (OR=1.15) 和心力衰竭 (OR=5.36) 的可能性更高.
- 并发性心血管疾病与使用典型和非典型抗精神病药物,抗焦虑药物,镇静剂,抗抑郁药和情绪稳定剂有关. 珀菲纳 (OR=22.06) 和原 (OR=7.09) 与心力衰竭有很强的联系.
结论:
- 在中国患有SSD的患者中,有四种不同的心血管疾病并发症模式,其中高血压和心力衰竭是突出的.
- 人口变化和精神药物使用与这些心血管疾病模式有显著的关联.
- 这些发现为优化SSD患者共病性心血管疾病的临床管理和治疗策略提供了宝贵的见解.
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