肠道密室微生物群通过酸英多尔调节肠道干细胞的循环和瘤发生
Shuning Zhang1,2, Lihua Peng1, Shyamal Goswami1
1Laboratory for Microbiota-Host Interactions, The Center for Microbes, Development and Health, Shanghai Institute of Immunity and Infection-Chinese Academy of Sciences, Shanghai, China.
Nature microbiology
|February 19, 2025
概括
一种特定的肠道细菌,Acinetobacter radioresistens,产生酸 (IAA),抑制肠道干细胞的循环,提供对结肠直肠癌发展的保护.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 癌症生物学 癌症生物学
背景情况:
- 肠道微生物群在肠道平衡和疾病中发挥着作用.
- 居住在肠道密室中的细菌的特定功能,特别是调节肠道干细胞 (ISC) 和结肠直肠癌 (CRC) 的发展,仍然在很大程度上是未知的.
研究的目的:
- 为了研究密室居民细菌在调节肠道干细胞和结肠直肠癌中的作用.
- 确定特定的细菌物种及其分泌的分子,影响ISC周转和CRC进展.
主要方法:
- 使用有机体模型对密室居民细菌的查.
- 使用CRC患者和APC小鼠的瘤切片进行抑制测定.
- 使用菌体对*Acinetobacter放射电阻*进行向清除.
- 分析信号通路,包括EphB2,烯碳化合物受体 (AhR) 和Wnt-β-catenin.
主要成果:
- *Acinetobacter radioresistens* 分泌着印酸 (IAA),从而抑制了ISC的循环.
- *A. radioresistens* 抑制了CRC患者瘤切片中的细胞增殖,并减少了小鼠模型中的肠道瘤发生.
- 向消除*A.放射电阻*增加了EphB2的表达,促进了ISC的周转和瘤发生.
- *A. radioresistens*的保护作用取决于IAA的产生和基碳化合物受体 (AhR).
结论:
- *Acinetobacter放射电阻*通过通过IAA-AhR-Wnt-β-catenin信号轴抑制ISC周转,在结直肠癌的发展中起着保护作用.
- 这项研究揭示了一种新的机制,通过该机制,肠道开始性细菌有助于维持肠道平衡,并防止瘤发生.
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