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Updated: May 27, 2025

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
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Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

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人类单细胞数据的机器学习模型中的偏差.

Theresa Willem1,2, Vladimir A Shitov3,4, Malte D Luecken3,4

  • 1TUM School for Medicine and Health, Institute of History and Ethics in Medicine, Technical University of Munich, Munich, Germany. theresa.willem@helmholtz-munich.de.

Nature cell biology
|February 19, 2025
PubMed
概括

单细胞分析中的机器学习提供了诊断见解,但容易产生各种偏见. 本研究确定了这些偏见,并提出了缓解方法,以确保可靠的结果.

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相关概念视频

Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
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