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Updated: Jun 26, 2026

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells
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模拟甲基酸盐水平升高对血管和代谢并发症的影响

Philippe Vangrieken1,2, Jean L J M Scheijen3, Paul M H Schiffers4

  • 1CARIM, Cardiovascular Research Institute Maastricht, Department of Internal Medicine, School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center+, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands. p.vangrieken@maastrichtuniversity.nl.

Scientific reports
|February 19, 2025
PubMed
概括

在小鼠中,长期暴露于甲基醇 (MGO) 增加了MGO水平,体重和血压. 这项研究没有发现对葡萄糖敏感性或内皮功能的影响,这表明MGO修饰胰岛素可能会影响血压.

关键词:
先进的糖化最终产品.糖尿病 糖尿病 糖尿病在高血压的高血压.胰岛素耐药性 胰岛素耐药性是一种代谢性毒性 代谢性毒性甲基格里奥克萨尔 (Methylglyoxal) 是一种

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Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...