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Updated: May 27, 2025

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
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对SPO11依赖的双链断裂形成的复合

Zhi Zheng1,2, Lyuqin Zheng2, Meret Arter2

  • 1Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature
|February 19, 2025
PubMed
概括

SPO11 蛋白启动 DNA 双链断裂 (DSB),这对变至关重要. 这项研究揭示了SPO11二元化如何控制其DNA裂变活性,平衡基本功能与安全性.

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The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
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