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Updated: May 27, 2025

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副体FGF21动态调节mTOR信号,以调节整个生命周期的胸腺功能

Sarah A Wedemeyer1, Nicholas E Jones1, Iwan G A Raza2

  • 1Department of Microbiology, Immunology, & Molecular Genetics, UT Health San Antonio, San Antonio, TX, USA.

Nature aging
|February 19, 2025
PubMed
概括

骨髓TEC衍生的FGF21 (纤维细胞生长因子21) 通过促进cTECs中的mTOR信号传递,使衰老的胸腺复苏. 这增强了T细胞功能和自我耐受性,为与年龄相关的免疫衰退提供了治疗潜力.

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