整合衰老和死亡率的环境和遗传结构
M Austin Argentieri1,2,3, Najaf Amin4, Alejo J Nevado-Holgado5
1Nuffield Department of Population Health, University of Oxford, Oxford, UK. aargentieri@mgh.harvard.edu.
Nature medicine
|February 19, 2025
概括
环境暴露,暴露组,显著影响衰老和死亡率超过遗传学. 暴露组解释了17%的死亡率变化,突出了其在健康和疾病风险方面的关键作用.
科学领域:
- 遗传学和环境健康
- 衰老研究研究 衰老研究
- 流行病学 流行病学
背景情况:
- 遗传因素和环境暴露 (暴露组) 都会影响人类的衰老和死亡率.
- 量化暴露基因与遗传学对衰老和过早死亡的相对影响对于公共卫生至关重要.
研究的目的:
- 量化暴露组和遗传学对衰老和过早死亡的独特贡献.
- 用英国生物银行数据确定与衰老和死亡相关的特定环境暴露.
主要方法:
- 在英国生物库参与者中,对所有原因的死亡率 (n=492,567) 和蛋白质年龄钟 (n=45,441) 的全暴露组关联分析.
- 评估已识别的暴露与与年龄相关的多重疾病,衰老生物标志物和疾病风险因素的关联.
- 多基因风险得分的解释力与死亡率和疾病发病率的暴露组的比较.
主要成果:
- 确定了25个与死亡率和蛋白质组衰老相关的独立环境暴露,也与多发病和疾病风险有关.
- 暴露组解释了17%的超越年龄和性别的额外死亡率变化,而多基因风险得分解释了<2%.
- 暴露组解释了肺,心脏和肝脏疾病的更多变异,而遗传学对痴呆症和某些癌症的影响更大.
结论:
- 暴露体在塑造死亡率和与年龄相关的疾病发病率方面发挥着重要作用,通常独立于遗传倾向.
- 研究结果提供了对环境和基因对衰老的贡献的全面地图,突出了健康干预的目标.
- 环境暴露对整个生命周期的疾病和死亡风险的不同模式有显著的影响.
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