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患者对长期艾滋病毒治疗的偏好:偏好异质性评估

Enrique M Saldarriaga¹, Brett Hauber^2,3, Douglas Barthold²

¹The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, University of Washington, 1959 Pacific St NE, Seattle, WA, 98107, USA. emsb@uw.edu.

BMC infectious diseases

|February 19, 2025

概括

长效抗逆转录病毒疗法 (LA-ART) 显示出改善艾滋病毒治疗坚持治疗的前景. 患者的偏好各不相同,有些人喜欢植入物或注射,而另一些人更喜欢每天服用口服药片或在家服用LA口服药片.

科学领域:

艾滋病毒/艾滋病治疗
药理学药理学是指药理学的学科.
公共卫生公共卫生

背景情况:

长效抗逆转录病毒疗法 (LA-ART) 是每天服用口服药物的替代方案,有可能提高艾滋病毒治疗的坚持.
了解患者对LA-ART的偏好对于其成功实施至关重要.

研究的目的:

调查艾滋病毒感染者 (PWH) 中对LA-ART的偏好异质性.
确定个体特征如何与对LA-ART模式的不同偏好有关.

主要方法:

一项对699名PWH的调查包括17个选择任务,比较假设的LA-ART选择 (口服,皮下注射,肌内注射,植入物) 与每日口服治疗.
隐性类型建模用于分析基于模式,频率,位置,注射疼痛和其他因素的偏好.
研究了确定偏好类和个体特征之间的关联.

主要成果:

出现了三个不同的偏好类别:LA-植入物 (29%),LA-口服或注射 (35%) 和每日或LA-口服 (36%).
两个类偏爱LA-ART (植入物或口服/注射),其特点是年龄较小,高等教育,坚持较低,注射厌恶程度较低.
LA-Implant组的病毒抑制率较低,更容易进入诊所;LA-Oral-or-Injection组的精神障碍率较高.

结论:

在PWH中对于LA-ART存在显著的偏好异质性.
根据个人偏好调整LA-ART干预措施,考虑年龄,坚持和特定健康状况等因素,可以改善治疗结果.

关键词:

离散的选择实验实验.长期起作用的ART治疗方法偏好的异质性偏好的异质性偏好诱导的诱导方式

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