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便免疫化学试验和挥发性有机化合物分析在检测结直肠息肉的诊断准确性:元分析

Asma Afzal^1,2, Yekaterina S Aranan³, Tom Roberts⁴

¹Department of Colorectal Surgery, North Tees & Hartlepool NHS Foundation Trust, Stockton-on-Tees, UK.

|February 20, 2025

概括

便免疫化学测试具有高特异性,但对于晚期腺瘤的敏感性较低. 挥发性有机化合物更敏感,结合这两种测试可以提高结直肠多体的检测率.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
诊断医学诊断医学

背景情况:

结肠直肠癌的早期检测依赖于识别癌前病变.
非侵入性查方法,如便免疫化学测试 (FIT) 已被确立用于结直肠癌,但不经常用于聚.
挥发性有机化合物 (VOC) 显示出癌症检测的潜力.

研究的目的:

为了确定FIT和VOC在检测结直肠多瘤的诊断准确度.
评估FIT和VOC在晚期腺瘤的联合诊断性能.

主要方法:

对原始文章的系统审查和元分析,报告了FIT和VOC在检测晚期腺瘤中的诊断测试准确性.
搜索了四个主要的数据库:MEDLINE,CINAHL,Embase和科学网络.
使用诊断准确性研究的质量评估工具评估研究质量;使用RStudio®进行元分析.

主要成果:

在审查中包括22个FIT和12个VOC文章;18个FIT和8个VOC研究符合元分析的条件.
对FIT的综合敏感性和特异性:36% (95%CI 30-41) 和89% (95%CI 86-91),AUC为0.65.
对挥发性有机化合物的综合敏感性和特异性:83% (95% CI 70-91) 和76% (95% CI 60-87),AUC 0.84.
结合FIT-VOCs的灵敏度:89%与67%的特异性.

结论:

对于晚期腺瘤,FIT表现出高特异性但低敏感性.
挥发性有机化合物分析为高级腺瘤检测提供了更高的灵敏度.
结合FIT和VOC显著提高了晚期结直肠腺瘤的检测率.

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