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基于聚合物纳米粒子的药物和生物活性化合物的向输送用于关节炎管理

Tanu Dixit¹, Anuradha Vaidya¹, Selvan Ravindran¹

¹Symbiosis School of Biological Sciences, Symbiosis International (Deemed University), Pune, India.

Future science OA

|February 20, 2025

概括

聚合物纳米粒子 (PNPs) 通过提高药物稳定性和减少副作用,为有针对性的关节炎治疗提供了一个有前途的方法. 为了临床应用,需要进一步开发.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

目前的关节炎疗法有其局限性.
需要有针对性的药物输送系统来克服这些局限性.

研究的目的:

审查聚合物纳米粒子 (PNPs) 针对性关节炎治疗的潜力.
探索PNP合成,药物输送机制和关节炎中的应用.

主要方法:

在PubMed,Scopus和Web of Science的综合文献搜索.
对用于关节炎治疗的聚合物纳米粒子研究的分析.

主要成果:

PNPs增强药物稳定性,使可控/持续释放,并减少系统性副作用.
生物相容的聚合物 (奇托桑,酸,PLGA) 和生物活性化合物 (黄素,白醇) 是有前途的.
临床前模型表明PNP的治疗效率得到了提高.

结论:

PNP提供了一种针对性,持续和安全的关节炎药物输送的变革性方法.
挑战包括快速清关和制造可扩展性.
临床翻译需要纳米粒子设计,个性化医学和生产方面的进步.

关键词:

关节炎是一种关节炎.生物相容性的生物相容性控制的药物释放控制的药物释放药物输送是药物输送的过程.这是一种炎症炎症炎症炎症.聚合物纳米粒子的聚合物纳米粒子.

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