相关实验视频

Updated: May 27, 2025

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System
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Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System

Published on: December 10, 2021

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在蛋白质结构的背景下重新审视亨廷丁活性和定位信号

Ray Truant1, Rachel J Harding2,3,4, Kaitlyn Neuman1

  • 1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.

Journal of Huntington's disease
|February 20, 2025
PubMed
概括

这项研究使用冷EM和人工智能驱动的建模重新审视了亨廷丁蛋白位址信号. 它提出了可测试的假设,说明多重胺扩张如何影响亨廷丁.

关键词:
3D 结构 3D 结构阿尔法折叠建模模型ATAXIN-1 的使用方法狩猎 狩猎 狩猎 狩猎局部化信号 局部化信号

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Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

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