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Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
Published on: February 27, 2018
亨廷顿病的经济负担:系统性审查
Pooja Gokhale1, Lorenzo Villa Zapata1
1Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Athens, GA, USA.
Journal of Huntington's disease
|February 20, 2025
概括
亨廷顿病 (HD) 给全球经济带来了巨大的负担,每年成本因地区而异. 了解这些经济影响对于资源配置和患者支持至关重要.
科学领域:
- 神经科学是一个神经科学.
- 卫生经济学 卫生经济学
- 公共卫生 公共卫生
背景情况:
- 亨廷顿病 (HD) 是一种自体主导的神经退行性疾病,导致渐进的运动,认知和精神衰退.
- 由于其衰弱性质,HD在全球范围内构成了重大的社会经济挑战.
研究的目的:
- 系统地审查和描述亨廷顿病带来的全球经济负担.
- 分析不同地理区域的与HD相关的直接,间接和总成本.
主要方法:
- 在主要数据库 (PubMed/MEDLINE, Web of Science, Cochrane Library) 进行了全面的文献搜索,截至2024年6月.
- 包括的研究评估了HD的直接,间接和/或总成本,并将成本转换为2024美元.
- 分析包括了来自15个国家的19篇全文文章,涵盖了1980-2024年.
主要成果:
- 亨廷顿病的年费用因地区而异:美洲 (2542美元至90515美元),欧洲 (40 000美元至215 020美元),亚洲 (1915美元至7132美元) 和大洋洲 (3678美元至8721美元).
- 挪威 (171,842美元) 和英国 (215,020美元) 报告的成本最高.
- 亚洲国家报告成本大幅降低,如中国 (6469美元) 和韩国 (6305美元).
结论:
- 疾病的全球经济负担是巨大的和高度可变的,受区域患病率,医疗保健系统和研究方法的影响.
- 局限性包括异质的成本报告,潜在的低估转换,以及缺乏疾病严重程度分层.
- 建议对疾病成本研究进行标准化,并开发质量评估工具,以提高可比性和资源分配.
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