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Updated: May 13, 2026

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在亨廷顿病的Q175DN小鼠模型中,尽管HTT聚合升高,但海马病理的缺乏仍然存在

Melissa A Solem1, Ross G Pelzel1, Nicholas B Rozema1

  • 1Department of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, MN, USA.

Journal of Huntington's disease
|February 20, 2025
PubMed
概括

亨廷顿病 (HD) 鼠标模型显示不同的神经病理. Q175DN小鼠表现出增强的突变亨廷丁 (mHTT) 聚合,但缺乏海马体变性,与条状神经元不同.

关键词:
在HTT中毒性毒性.亨廷顿病就是亨廷顿病.Q175DN Q175DN Q175DN Q175DN Q175DN Q175DN Q175DN Q175DN在海马体内,海马体变异型的狩猎条纹体的条纹体.

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Huntington Disease l: Introduction01:21

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...