检测小孩在儿童时期服用无硫醇的HibTITER®的不良结果
Karl Jablonowski1, Brian Hooker1
1Children's Health Defense, Franklin Lakes, NJ, USA.
The International journal of risk & safety in medicine
|February 20, 2025
概括
HibTITER疫苗与儿童的19种不良健康结果有关,包括呼吸道和传染病. 使用VAERS数据库证实了这些发现,影响了数百万接种疫苗的人.
科学领域:
- 儿科免疫学 儿科免疫学
- 疫苗安全研究疫苗安全研究
- 公共卫生监督是对公共卫生的监督.
背景情况:
- 乙型流感血球菌 (Hemophilus influenzae type b,简称HIB) 是一种带有格拉姆阴性细菌,对儿科和老年人群构成风险.
- HIB感染可能导致严重的并发症,包括永久的后果和死亡.
- HibTITER疫苗是一种无硫醇配方,用于预防HIB感染.
研究的目的:
- 为了确定与无硫醇的HibTITER疫苗相关的不良健康结果.
- 分析来自佛罗里达州医疗补助 (2003-2007) 的大量儿科疫苗接种数据集.
- 通过疫苗不良事件报告系统 (VAERS) 证实发现.
主要方法:
- 对HIB疫苗接种者的佛罗里达医疗补助数据 (n=277,484) 的回顾性分析.
- 接受HibTITER和接受其他HIB疫苗的人之间的不良结果的比较.
- 统计分析使用严格的p值,Medicaid数据为<0.0001,VAERS数据为p<0.05,<0.001,<0.0001.
主要成果:
- 19个ICD-9代码显示,在30天内与HibTITER疫苗接种具有统计学意义的正相关性 (p<0.0001).
- 其中14种情况得到了VAERS数据库中的数据的证实.
- 不良结果跨越多个系统,包括呼吸道 (喘),胃肠道,耳鼻喉,皮肤和通用感染 (结核病).
结论:
- 与其他HIB疫苗相比,HibTITER疫苗与19种疾病的发生率显著增加有关.
- 这些发现通过VAERS数据分析得到了独立验证.
- 这些结果对数百万人接种HibTITER疫苗的健康有重大影响.
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