来自马来西亚现实世界的深度脑刺激队伍的新见解
Alfand Marl F Dy Closas1,2, Ai Huey Tan1,2, Yi Wen Tay3
1Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Journal of Parkinson's disease
|February 20, 2025
概括
深度大脑刺激 (DBS) 在马来西亚对帕金森病有效,结果良好,并发症率低. 然而,接入仍然有限,特别是政府资助的患者,突出了先进治疗接入的区域差异.
科学领域:
- 神经外科 神经外科
- 神经学 神经学
- 运动障碍 运动障碍
背景情况:
- 深度大脑刺激 (DBS) 是对运动障碍的关键治疗方法,但其在发展中国家的可用性有限.
- 关于东南亚的DBS利用和结果的数据很少,需要进行当地表征.
研究的目的:
- 描述深度大脑刺激 (DBS) 队列,并评估马来西亚四级医学中心的结果.
- 分析DBS患者手术后药物减少和并发症率.
主要方法:
- 马来亚大学对DBS相关手术的回顾性图表审查.
- 收集的数据包括临床人口统计,遗传和结果信息.
- 专注于手术后的药物减少 (莱沃多巴相当的每日剂量) 和并发症.
主要成果:
- 149名帕金森病 (PD) 患者接受了DBS治疗,主要针对体内亚体核.
- 观察到显著的药物减少:在DBS后6-12个月内,LEDD的中位数减少了440.5 mg/天.
- 低并发症率 (1.9%的症状内出血) 与国际标准相比较;16%的测试患者患有GBA1变异.
结论:
- 这项研究是东南亚最大的DBS报告,证明了程序的有效性和安全性.
- 已注意到高频率的GBA1相关帕金森病,在短期PD患者中具有良好的结果.
- 在获得设备辅助疗法方面,发现了严重的区域不平等.
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