新生儿重症监护室设计对新生儿阿片类药物戒断综合征的婴儿的影响
Katherine Nyman1,2, Elyse Decker3, Kristin Ronan4
1University of California San Diego School of Medicine, San Diego, CA, USA.
Journal of neonatal-perinatal medicine
|February 20, 2025
概括
新生儿阿片类药物戒断综合征 (NOWS) 在单个家庭房间 (SFR) 新生儿重症监护室 (NICU) 的护理导致了更长的停留时间,尽管母乳养增加. 这种NICU设计可能会对NOWS婴儿的结果产生意想不到的后果.
科学领域:
- 新生儿护理 新生儿护理
- 儿科药理学 儿科药理学
- 医疗保健设施的设计
背景情况:
- 新生儿阿片类药物戒断综合征 (NOWS) 需要密集,长时间的新生儿重症监护室 (NICU) 护理.
- 幼儿重症监护室物理环境对NOWS治疗和停留时间 (LOS) 的影响尚未完全理解.
研究的目的:
- 调查NICU设计,特别是开放式设计 (OBD) 与单个家庭房间 (SFR) 环境对诊断为NOWS的婴儿的治疗和NICU-LOS的影响.
主要方法:
- 一个回顾性图表回顾分析了2013-2018年NOWS.婴儿的数据.
- 多变量线性回归对OBD和SFRNICU之间的NICU-LOS进行了比较,并对共变量进行了调整.
- 数据包括人口统计,药物使用和LOS特征.
主要成果:
- 在SFRNICU的婴儿中,母乳养率较高 (26%vs. 6%),但NICU-LOS的时间比OBD的婴儿长1.3倍 (p=0.0163).
- 在SFRNICU中,药物治疗的使用率略高 (86%对76%,p=0.059).
- 在两种NICU设计之间,吗啡累积剂量没有显著差异.
结论:
- 尽管母乳养率有所改善,但SFR NICU设计与NOWS婴儿的NICU-LOS增加有关.
- 虽然SFR单位提供隐私,但对这种脆弱人群的逗留时间的潜在意外影响需要进一步调查.
相关概念视频
Analgesia and Pain Management
422
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
422
Opioid Analgesics: Synthetic and Semisynthetic Opioids
207
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
207
Opioid Analgesics: Morphine and Other Natural Cogeners
165
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
165


