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Updated: May 27, 2025

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开发Zafirlukast类似物以通过提异构酶抑制改善抗血栓活性

Justine A Keovilay1,2, Kaitlind C Howard3, Kirk A Taylor2

  • 1Department of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA (J.A.K., S.E.W., M.K.S., D.R.K.).

Arteriosclerosis, thrombosis, and vascular biology
|February 20, 2025
PubMed
概括

研究人员开发了一种新的zafirlukast (ZAF) 模拟物,化合物21,它显示出优异的醇异构酶抑制和抗血栓活性. 这种化合物有效地抑制血小板激活和血栓形成,而不会增加出血风险,提供了一个有前途的治疗候选者.

关键词:
药物重新定位 药物重新定位这些异构酶是异构酶.蛋白质二硫化物-异构酶是蛋白质二硫化物.结构-活动关系关系.血栓形成的原因是血栓形成.

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