在社区获得的肺炎中使用MeMed BV进行宿主反应测试:从英国NHS的角度来看,经济评估
Emily Gregg1, Sara Graziadio1, William Green1
1York Health Economics Consortium (YHEC), University of York, York, UK.
JAC-antimicrobial resistance
|February 20, 2025
概括
在社区获得性肺炎 (CAP) 病例中,MeMed BV (MMBV) 测试可以帮助区分细菌和病毒感染. 预计实施MMBV将节省成本,并改善成人和儿科患者的抗生素管理.
科学领域:
- 医学诊断 医学诊断 医学诊断
- 卫生经济学 卫生经济学
- 传染性疾病 传染性疾病
背景情况:
- 社区获得性肺炎 (CAP) 是住院和死亡的重要原因.
- 一种新的宿主反应诊断,MeMed BV (MMBV),旨在区分细菌和病毒感染,以加强CAP管理.
- 目前用于CAP的诊断方法可能耗时,可能导致不适当的抗生素使用.
研究的目的:
- 评估使用MeMed BV (MMBV) 测试以指导英国CAP患者的抗生素处方决策的成本效益.
- 评估将MMBV纳入CAP管理的标准护理途径的经济影响.
主要方法:
- 从英国国家卫生服务 (NHS) 的角度开发了一个经济模型,以确定实施MMBV的每人成本.
- 对护理途径进行了定性分析,将标准护理 (SOC) 与SOC加MMBV (SOC + MMBV) 相比较.
主要成果:
- 据估计,SOC + MMBV策略每1000名疑似CAP患者中,成年人节省134,018英,儿童节省105,750英的成本.
- 节约归因于减少抗生素使用,更少的诊断测试和减少住院治疗.
- 敏感性分析确定了成本模型的关键驱动因素,包括测试的特异性和敏感性.
结论:
- 预计将MMBV纳入CAP管理的临床实践将节省成本.
- 实施MMBV支持成人和儿科CAP病例中的抗菌药物管理工作.
- MMBV为CAP治疗的临床和经济结果提供了潜在的改善.
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