相关实验视频

Updated: May 27, 2025

High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity

High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity

Published on: November 16, 2016

血中阿齐思罗米的度和与肠热患者的临床结果的相关性

Rini Bandyopadhyay¹, Sumith K Mathew², Balaji Veeraraghavan³

¹Department of Infectious Diseases, Christian Medical College, Vellore, Tamilnadu, India.

JAC-antimicrobial resistance

|February 20, 2025

概括

阿齐思罗米是有效的治疗广泛耐药性肠热,即使在低血度. 这项研究表明,在接受阿齐思罗米治疗XDR肠热的患者中,治疗结果是成功的.

科学领域:

药理学药理学是指药理学的学科.
传染性疾病传染性疾病
微生物学微生物学

背景情况:

阿齐思罗米是广泛耐药性肠热 (XDR) 的唯一口服治疗选择.
现有有限的研究表明,阿齐思罗米辛水平与XDR肠热的治疗成功有关.

研究的目的:

测量血清阿齐思罗米辛水平在患有血培养阳性肠热的患者.
为了将这些水平与临床和微生物治疗结果相关联.

主要方法:

一项针对25名XDR肠热患者的成年人进行的前性队列研究.
在7天每天一次20毫克/千克的剂量后,在多个时间点测量了血清中阿齐思罗米水平.
确定了最小抑制度 (MIC) 和血度 (LC-MS);记录了临床结果.

主要成果:

沙门氏菌Typhi和Paratyphi是引起病原体.
中位数阿齐思罗米辛MIC为4mg/L,范围为3-12mg/L.
尽管血的低谷和高峰度 (例如,Cmax/MIC 0.29),但所有患者都实现了临床和微生物治疗,没有死亡率.

结论:

阿齐思罗米在治疗XDR肠热方面表现出有效性.
尽管亚治疗性细胞外阿齐思罗米辛的血水平,但观察到治疗的成功.
这些发现支持阿齐思罗米用于XDR肠热的使用.

更多相关视频

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

相关概念视频

Drug Concentration Versus Time Correlation

Drug Concentration Versus Time Correlation

The plasma drug concentration-time curve is a crucial tool in pharmacokinetics, representing the drug's concentration in plasma at different time intervals post-administration. This curve illustrates the drug's journey from absorption into the systemic circulation, distribution to body tissues, and eventual elimination through excretion or biotransformation.
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the...

Time Course of Drug Effect

Time Course of Drug Effect

The progression of a drug's impact can be analyzed by examining both the concentration-time course and the effect-time course. The concentration-time course is determined by the drug's half-life and is influenced by factors such as its pharmacokinetics, including absorption, distribution, metabolism, and elimination. The effect of the drug is often related to its concentration in the plasma and is calculated using the maximum drug effect and the plasma concentration that generates 50...