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对肠道微生物群,miRNA和人类病理之间的双向相互作用进行系统审查

Lorenzo Drago^1,2, Luigi Regenburgh De La Motte¹, Loredana Deflorio¹

¹UOC Laboratory of Clinical Medicine with Specialized Areas, IRCCS MultiMedica, Milan, Italy.

Frontiers in microbiology

|February 20, 2025

概括

微RNA (miRNA) 和肠道微生物组双向相互作用,影响慢性疾病. 本综述强调了miRNAs作为微生物组相关炎症的潜在生物标志物,并探索了治疗策略.

科学领域:

人类生理学和疾病
微生物组研究的研究.
分子生物学分子生物学

背景情况:

微RNA (miRNA) 和肠道微生物群对人类健康至关重要.
它们的双向相互作用越来越多地与慢性疾病有关.
失调影响代谢,免疫和炎症通路.

研究的目的:

在慢性疾病中对miRNA-肠道微生物群相互作用的人类研究 (2020-2024) 进行系统审查.
探索miRNAs在调节肠道微生物群中的作用,反之亦然.
确定潜在的基于miRNA的治疗策略.

主要方法:

2020年至2024年间发表的人类研究的系统文献综述.
纳入标准集中在研究特定人类疾病中的miRNA-肠道微生物群相互作用的研究上.
排除体外,体内和体内研究,以保持翻译相关性.

主要成果:

miRNAs可以调节肠道微生物组的组成和功能,影响宿主代谢和免疫力.
肠道微生物群影响宿主miRNA的表达,影响炎症反应和疾病风险.
患者中稳定和丰富的miRNA显示出作为微生物驱动炎症的生物标志物具有前途.

结论:

miRNA-肠道微生物群的相互作用是胃肠道,自身免疫,代谢和神经发育障碍的核心.
miRNAs对细菌菌株表现出调控作用,并与疾病状态有关.
基于miRNA的疗法有可能恢复微生物平衡并减轻炎症.

关键词:

阿尔茨海默氏症 (AD) 是一种疾病.克罗恩氏病 (CD) 是一种疾病.心血管疾病心血管疾病肠道微生物瘤是什么意思炎症性肠病 (IBD) 是一种炎症性肠病.大型抑郁症 (MDD) 是一种主要的抑郁症.这是一个小RNARNA.

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