内分类固醇和炎症标志物的性别差异与创伤后应激障碍相关
Therese A Rajasekera1,2,3, Anna Joseph1, Hui Pan4
1Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
medRxiv : the preprint server for health sciences
|February 20, 2025
概括
创伤后应激障碍 (PTSD) 中的性别差异与不同的生物机制有关. 患有PTSD的男性表现出较低的内分泌大麻素水平,而女性表现出炎症增加,这表明病理生理学不同.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 创伤后应激障碍 (PTSD) 不成比例地影响女性,这种性别差异的生物学基础仍然不清楚.
- 改变的内分泌大麻素 (eCB) 系统功能和增加的炎症与PTSD病理生理学有关,并可能解释风险和严重性的性别差异.
- 这项研究调查了与对照人群相比,患有PTSD的人群中循环eCB和外周炎症标志物的性别特异性差异.
研究的目的:
- 检查患有创伤后应激障碍 (PTSD) 个体内内大麻素 (eCB) 和炎症标志物水平的基于性别的差异.
- 阐明潜在的生物学机制,有助于PTSD在女性中更高的患病率.
- 探索这些生物学差异是否在伴随性严重抑郁症患者中持续存在.
主要方法:
- 对88名患有PTSD和85名健康对照人 (HC) 的血清样本进行了回顾性分析.
- 循环内分泌素 (安纳米德,2-AG,OEA,AA) 和炎症标志物 (IL-1β,IL-6,IL-8,IL-18,TNFα,CRP) 的量化.
- 使用线性回归和t测试进行统计分析,以根据疾病状态和性别识别差异性丰度,并对共发性MDD和基因型进行调整.
主要成果:
- 与对照组和女性子组相比,男性PTSD患者的安纳胺 (AEA),阿拉基酸 (AA) 和乙醇胺 (OEA) 含量显著降低.
- 女性PTSD患者表现出高水平的互白素-6 (IL-6) 和互白素-8 (IL-8).
- 与对照组相比,男性和女性PTSD患者表现出瘤亡因子α (TNFα) 度的增加.
结论:
- 这项研究首次揭示,在患有PTSD的女性中没有观察到内分泌大麻素 (eCB) 水平下降.
- 与男性相比,患有PTSD的女性呈现出更广泛的炎症标志物,这表明与男性相比有不同的生物途径.
- 这些发现表明,PTSD背后的生物学机制在性别之间可能存在显著差异.
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