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重新评估脂肪和头癌之间的联系:孟德尔的随机化研究

Fernanda Morales-Berstein^1,2, Jasmine Khouja^1,2, Mark Gormley^1,2,3

¹MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.

medRxiv : the preprint server for health sciences

|February 20, 2025

概括

这项研究没有发现脂肪和头癌 (HNC) 风险之间的因果关系. 孟德尔的随机化分析,考虑到吸烟,表明体重指数 (BMI) 和其他措施不会增加HNC风险.

科学领域:

遗传学是一个遗传学.
流行病学流行病学
在瘤学瘤学.

背景情况:

肥胖与增加头癌 (HNC) 风险有关.
之前关于吸烟者的体重指数 (BMI) 和HNC风险的研究被混了.
在之前的孟德尔随机化 (MR) 研究中,有限的统计能力阻碍了因果推理.

研究的目的:

使用最大可用的全基因组关联研究 (GWAS) 数据,调查脂肪和HNC风险之间的因果关系.
分析各种子部位的HNC风险,包括口腔癌,喉癌,喉癌和喉癌.
为了评估脂肪测量对HNC风险的直接影响,调整吸烟行为.

主要方法:

使用了两个样本的MR框架与大规模的GWAS数据用于BMI,腰与部比 (WHR) 和腰围.
使用逆方差加权 (IVW) MR和多重灵敏度分析 (加权中位数,MR-Egger,MR-PRESSO,CAUSE).
应用多变量MR (MVMR) 来考虑吸烟,这是已知的HNC风险因素.

主要成果:

基因预测较高的BMI显示,在不变的MR中,整体HNC的边界风险增加 (OR=1.17,p=0.03).
当吸烟被纳入MVMR模型 (OR=0.96,p=0.64) 时,这种关联减弱并变得无意义.
在基因预测的WHR或腰围和HNC风险之间没有发现显著的关联.

结论:

肥胖,包括BMI,WHR和腰围,似乎不会对头癌风险产生因果影响.
BMI和HNC风险之间的初始关联可能会被吸烟等因素所混.
使用强大的MR方法进行进一步的调查证实,没有直接的因果关系.

关键词:

头癌是头部和部的癌症.门德尔的随机化肥胖症是一种脂肪性.身体质量指数 (BMI) 是什么?腰围腰围腰围腰围腰部与部的比率是什么

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