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蛋白质组与BMI波动和长期变化的关联:一项长达40年的随访研究
Alvaro Obeso1,2, Gabin Drouard3, Teemu Palviainen3
1Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country, Bilbao, Spain.
medRxiv : the preprint server for health sciences
|February 20, 2025
概括
这项研究揭示了血蛋白与长期体重指数 (BMI) 变化和波动之间的重要联系. 环境因素在整个成年期塑造这些蛋白质组的关联中起着关键作用.
科学领域:
- 心血管科学 心血管科学
- 代谢科学 代谢科学
- 蛋白质组学是指蛋白质组学.
- 双胞胎研究 双胞胎研究
背景情况:
- 对蛋白质组与长期体重增加的关联的理解有限,因为大多数研究都是基于干预的.
- 目前尚不清楚血蛋白是否与身体质量指数 (BMI) 随时间的波动有关.
- 需要调查与心脏代谢和炎症等离子体蛋白质相关的长期BMI变化和波动.
研究的目的:
- 调查长期的BMI变化和波动与1000多种血蛋白之间的关联.
- 检查BMI (PRSBMI) 和蛋白质关联的多基因风险得分之间的关系.
- 探索PRSBMI和基线BMI之间的蛋白质-BMI关系之间的相互作用.
主要方法:
- 利用了304名芬兰成年双胞胎的数据,在五个时间点 (1975-2014) 中测量了BMI.
- 分析了血液样本中的蛋白质组数据,使用线性混合效应模型和单胞胎双胞胎内对分析.
- 计算的BMI轨迹,BMI变化率和BMI波动;评估了与1,231个血蛋白和PRS的关联.
主要成果:
- 135种与长期BMI变化相关的蛋白质,17种与BMI波动相关;在双胞胎内对分析中,12种仍然显著.
- PRSBMI与BMI变化相关,但与波动无关.
- 观察到CD72蛋白与基线BMI之间的单一相互作用,没有显著的PRSBMI蛋白相互作用影响BMI趋势.
结论:
- 血蛋白与长期的BMI变化和波动之间存在显著的关联.
- 没有证据表明PRSBMI-蛋白相互作用显著影响BMI趋势.
- 环境因素在很大程度上影响了成年期的蛋白质组-BMI关联.
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