肌间附着组织和肌肉功能在维护血液透析的患者
R Gulsah Dilaver1, Mert Demirci1, Rachelle Crescenzi2
1Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, USA.
medRxiv : the preprint server for health sciences
|February 20, 2025
概括
肌肉间脂肪组织 (IMAT) 在维持血液透析患者中积累,与炎症和肌肉强度降低相关. 针对IMAT可能会改善慢性病 (CKD) 的结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢过程中的代谢.
- 身体组成 身体构成
背景情况:
- 肉类 (肌肉质量和力量的损失) 在晚期慢性病 (CKD) 中很普遍.
- 肌肉间脂肪组织 (IMAT) 积累与慢性疾病中的代谢和功能问题有关.
- 在维持血液透析 (MHD) 患者中了解IMAT对于管理CKD并发症至关重要.
研究的目的:
- 为了评估MHD患者的IMAT积累.
- 研究IMAT与MHD患者的代谢标志物和身体表现的相关性.
主要方法:
- 横截面研究比较了25名MHD患者和23名对照组.
- 通过使用MRI测量牛犊肌肉脂肪与肌肉的比率来测量IMAT.
- 评估身体组成,代谢标志物 (hs-CRP,TNF-α,IL-6,胰岛素抵抗) 和手握强度.
主要成果:
- 在MHD患者中,IMAT积累明显高于对照组 (p < 0.01).
- 在MHD患者中,炎症标志物 (TNF-α,IL-6,hs-CRP) 的升高.
- 在整个队列中,IMAT与手握强度有负相关性 (p < 0.01).
结论:
- 在MHD患者中,IMAT积累是一个重要的发现.
- 在晚期CKD中,IMAT与炎症和肌肉功能受损有关.
- 针对IMAT提供了一个潜在的治疗策略,以改善CKD患者的治疗结果.
相关概念视频
Hypodermis
3.9K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
3.9K
External Anatomy of the Kidney
690
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
690
Dialysis
252
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
252
Heart Failure Drugs: Diuretics
334
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
334
Loose Connective Tissue
6.8K
Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
6.8K


