基因分数与早产婴儿出生体重的关联,与早产婴儿和早产婴儿相比
Robin N Beaumont1, Sarah J Kotecha2, Shannon J Simpson3,4
1Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.
medRxiv : the preprint server for health sciences
|February 20, 2025
概括
遗传因素对早产和早产婴儿的出生体重有影响,但它们的影响在早产婴儿中不那么明显,特别是在早期的怀孕中. 环境和胎盘因素可能在早产体重方面发挥更大的作用.
科学领域:
- 遗传学 遗传学 是一个
- 新生儿医学 新生儿医学
- 围产期护理 围产期护理
背景情况:
- 在早产儿出生时体重较低与新生儿并发症增加有关.
- 了解影响早产体重的因素对于改善产前和产周护理至关重要.
- 对出生体重的遗传贡献在预产婴儿中已经得到了很好的证实,但在早产婴儿中不太了解.
研究的目的:
- 为了比较出生体重 (BW-GS) 的遗传分数与早产婴儿和满期婴儿的实际出生体重的关联.
- 研究在早产婴儿的不同妊娠期对出生体重的遗传影响.
主要方法:
- 使用线性回归分析来测试BW-GS与出生体重之间的关联.
- 数据包括四个数据集中的1,416名早产婴儿和15,253名单产婴儿.
- 分析对祖先的主要组成部分进行了调整,并进行了元分析.
主要成果:
- 在预产婴儿中,BW-GS增加1个标准偏差 (SD) 与出生体重增加1.20 SD有关.
- 在早产婴儿中,BW-GS增加1个SD与出生体重增加0.76个SD有关,这表明效果大小较小.
- 在早产婴儿中,BW-GS与出生体重之间的关联随着妊娠时间的增加而加强.
结论:
- 来自终产婴儿变异的遗传分数也会影响早产婴儿的出生体重.
- 对出生体重的遗传影响在早产婴儿中相比于晚产婴儿的影响较小,特别是在早期的怀孕中.
- 其他因素,可能是环境,胎盘或不同的遗传影响,在确定早产婴儿的出生体重方面可能更为重要.
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