酒精使用严重程度和多基因风险对年轻成年人灰色质量的影响
Yu Chen1, Huey-Ting Li2, Xingguang Luo1
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, U.S.A.
medRxiv : the preprint server for health sciences
|February 20, 2025
概括
对酒精依赖的遗传风险可能会增加某些区域的大脑灰质量的数量,与酒精不同.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 神经成像是一种神经成像.
背景情况:
- 滥用酒精有遗传的基础.
- 慢性酒精使用与大脑灰质体积 (GMVs) 的减少有关.
- 基因风险对转基因病毒的独立影响,与酒精暴露分开,尚未得到充分理解.
研究的目的:
- 为了研究酒精依赖的遗传风险如何影响大脑GMV独立于酒精消费.
- 识别与饮酒严重程度和对滥用酒精的遗传倾向相关的独特神经标志物.
主要方法:
- 利用了来自995个神经类型成年人 (年龄22-35岁) 的人类结合体项目数据.
- 采用基于voxel的形态测量来分析166个大脑区域的GMV.
- 酒精依赖的计算多基因风险评分 (PRS) 和量化的酒精使用严重程度 (PC1).
- 进行了线性回归分析,控制年龄,性别,种族和总内体积.
主要成果:
- 酒精使用的严重程度 (PC1) 与右侧胰岛和Heschl's gyrus中的GMVs负相关.
- 遗传风险评分 (PRS) 与左后轨道前皮层,乳头内层核和语言回旋中的GMV正相关.
- 研究结果表明,对酒精依赖的遗传倾向可能与更大的区域大脑体积有关.
结论:
- 饮酒严重程度和滥用酒精的遗传风险与大脑区域体积的不同模式有关.
- 酒精依赖的遗传因素可能导致奖励,情绪和突出回路的体积增加,与慢性酒精暴露的体积减少形成鲜明对比.
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