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在α-synuclein依赖的神经退行症中,AKT抑制的作用

Bedri Ranxhi1, Zoya R Bangash1, Zachary M Chbihi1

  • 1Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI, United States.

Frontiers in molecular neuroscience
|February 20, 2025
PubMed
概括

抑制AKT通路通过降低有毒的α-synuclein (α-Syn) 蛋白水平,在帕金森病模型中改善了生存和运动功能.

关键词:
在 AKT AKT 里面.在 NF-κBB 中.帕金森病是帕金森氏症的一种疾病.神经退行性疾病是一种神经退行性疾病.蛋白质错误折叠障碍 蛋白质错误折叠障碍蛋白质病变是一种蛋白质病变.综核蛋白异常症 (synucleinopathy) 是一种同核蛋白异常症.α-synuclein 是一种同核蛋白.

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