建议使用现实数据对经常要求的激素进行三角值检查限值
Sunghwan Shin1, Shinae Yu2, Sollip Kim3
1Department of Laboratory Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.
Biochemia medica
|February 20, 2025
概括
这项研究提出了常见激素的基于证据的三角洲检查限值 (DCL),提高了实验室的准确性. 对皮质醇,PTH和益生菌的建议DCL通过确保可靠的激素检测来提高患者的护理.
科学领域:
- 临床化学 临床化学
- 实验室医学 实验室医学
- 内分泌学 在内分泌学.
背景情况:
- 对于荷尔蒙测试的三角检查限值 (DCL) 存在有限的研究.
- 在实验室中经常使用任意的DCL,可能会影响准确性.
- 建立基于证据的DCL对于可靠的激素检测至关重要.
研究的目的:
- 为常见要求的激素提出验证的DCL.
- 为了比较住院/急诊和门诊机构之间的DCL.
- 在临床实验室中为DCL实施提供基础.
主要方法:
- 分析了来自韩国五所大学医院的59,657个配对激素结果.
- 使用绝对三角差 (absDD) 和绝对三角百分比变化 (absDPC) 建立DCL,截止率为5%.
- 在住院/急诊 (IE) 和门诊 (O) 组中DCL的比较.
主要成果:
- DCLs显示4.3%至6.4%的值超出限值,与5%的截止值保持一致.
- 对于ACTH,皮质醇,PTH和益生菌素,absDD DCL在各组之间有所不同.
- 联合DCL显示了IE和O组之间的ACTH和皮质醇结果的显著差异.
结论:
- 建议对皮质醇,PTH和益生菌素进行联合absDPCDCL.
- 根据临床环境 (IE与O),ACTH需要单独的DCL.
- 这些数据驱动的DCL为临床激素检测提供了可靠的框架.
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