评估乳腺外帕杰特病的死亡风险和原因:基于人口的研究的见解
Xiaohui Qiu1, Dong-Dong Yu2, Hui Dong3
1Department of Nursing, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Translational cancer research
|February 20, 2025
概括
乳腺外帕杰特病 (EMPD) 患者的死亡率通常是由于非癌症原因,特别是在局部阶段. 与一般人群相比,局部EMPD的整体死亡风险没有增加.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 乳腺外帕杰特病 (EMPD) 患者的死亡原因尚不清楚.
- 了解死亡率模式对于患者管理和生存分析至关重要.
研究的目的:
- 调查和分析被诊断患有乳腺外帕杰特病 (EMPD) 的患者死亡原因.
- 通过使用标准化死亡率 (SMRs) 将EMPD患者的死亡率与普通人群进行比较.
主要方法:
- 从SEER数据库 (2000-2019) 中对1,002名EMPD患者进行了回顾性队列分析.
- 使用标准化死亡率 (SMR) 来比较EMPD患者的死亡率与一般人群.
- 检查的死亡原因,包括癌症和与癌症无关的疾病,按疾病阶段分层.
主要成果:
- 非癌症相关的死亡人数占局部EMPD死亡人数的70%以上,区域/远程EMPD死亡人数的40%.
- 与普通人群相比,EMPD患者的全因死亡率总体较高 (SMR,1.91).
- 心血管和脑血管疾病是主要的非癌症死亡原因;年轻患者 (<60岁) 的SMR较低.
结论:
- 非癌症相关的死亡是所有阶段的EMPD患者死亡的重要原因.
- 虽然患恶性瘤的死亡风险较高,但局部EMPD的总体死亡风险与一般人群相比并没有显著增加.
- 这些发现提供了对EMPD患者死亡原因的全面分析,强调了管理非癌症并发症的重要性.
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