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治疗开始八年后出现的芬戈利莫德相关的中央血清视网膜病变:一个病例报告
Panos Gartaganis1, Panagiotis Stavrakas2, Evita Evangelia Christou3
1Department of Ophthalmology, 251 Hellenic Airforce General Hospital, Athens, Greece.
Maedica
|February 20, 2025
概括
多发性硬化症的长期fingolimod治疗可能会导致中央血清视网膜病变 (CSR). 转换为二甲基烟酸盐解决了CSR,显示治疗变化可以逆转眼部并发症.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 芬戈利莫德是复发性复发性多发性硬化症的关键治疗方法.
- 眼部不良反应是已知的fingolimod治疗的并发症.
- 中央血清性视网膜病变 (CSR) 是一种罕见但显著的眼部副作用.
研究的目的:
- 报告长期中枢血清性视网膜病变 (CSR) 在接受fingolimod治疗的患者中发生的病例.
- 讨论fingolimod相关的CSR的管理和结果.
- 为了突出长期使用fingolimod可能出现晚期发病的眼部并发症.
主要方法:
- 一个53岁的患有多发性硬化症的女性长期接受fingolimod的病例报告.
- 眼科检查显示CSR变化.
- 用局部尼帕芬雅克治疗,然后切换fingolimod到二甲基烟酸盐.
主要成果:
- 患者在开始fingolimod.8年后发展了CSR.
- 最初使用局部尼帕菲纳克的治疗导致液体分离.
- 在停止服用尼帕菲纳克后,CSR的复发发生.
- 转换为二甲基烟酸盐稳定了病情,在随访期间没有复发.
结论:
- 芬戈利莫德可以诱导CSR,即使在长期治疗后.
- 眼部并发症可能在治疗过程中晚些时候出现.
- 停止或切换fingolimod可能会逆转CSR并保持视觉功能.
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