难以管理的轴性脊柱关节炎
Evgenia Emmanouilidou1, Irini D Flouri1, Antonios Bertsias1
1Rheumatology and Clinical Immunology, University Hospital of Heraklion and University of Crete Medical School, Heraklion, Greece.
Mediterranean journal of rheumatology
|February 20, 2025
概括
难以管理的轴性脊椎关节炎 (axSpA) 影响了对多种治疗有抗性的患者. 了解D2M axSpA因素和管理对于改善患者的治疗结果至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 轴性脊柱关节炎 (axSpA) 呈现出各种表现和并发症.
- 许多axSpA患者对可用的疾病修饰性抗风湿药物 (DMARDs) 呈现耐药性.
- 耐药性源于炎症和非炎症因素,使治疗复杂化.
研究的目的:
- 审查难以管理 (D2M) axSpA的概念和证据.
- 澄清D2M axSpA的定义,流行率和贡献因素.
- 讨论当前的管理,并建议D2M axSpA患者的策略.
主要方法:
- 在Medline/PubMed,Scopus和谷歌学者的文献搜索.
- 关于D2M axSpA. 的全文文章的审查.
- 关于D2M axSpA定义和管理的当前证据的综合.
主要成果:
- 术语D2M axSpA描述了尽管有≥2种生物/向合成DMARDs,但仍然存在持续的症状.
- 耐治疗性疾病是一种D2M axSpA亚型,具有活跃的炎症.
- 定义和文献目前有限而多样化.
结论:
- D2M axSpA代表了一个重大的临床挑战.
- 需要进一步的研究来规范定义和探索治疗策略.
- 针对性的方法对于管理这一具有挑战性的患者子组至关重要.
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