骨质疏松症在脊椎骨关节病变中的悖论
Andreas Angelopoulos1, Ioannis Kouverianos2, Dimitrios Daoussis3
1General Hospital of East Achaia, Aigio, Greece.
Mediterranean journal of rheumatology
|February 20, 2025
概括
骨质疏松症 (OP) 是轴性脊柱炎 (axSpA) 的常见并发症,可能是由炎症驱动的. 然而,在牛皮关节炎 (PsA) 中的OP可能与治疗有关,而不是疾病病理生理学.
科学领域:
- 类风湿病学 类风湿病学
- 骨的新陈代谢 骨的新陈代谢
- 炎症性疾病 炎症性疾病
背景情况:
- 脊椎关节炎 (SpA) 包括影响脊椎和关节的炎症性疾病,特别是轴性脊椎关节炎 (axSpA) 和牛皮关节炎 (PsA).
- 尽管在SPA中形成了新的骨,但骨矿物质密度 (BMD) 可以矛盾地减少,表明潜在的骨损失.
- 骨质疏松症 (OP) 是 SpA 患者的一个重大问题,影响骨健康和生活质量.
研究的目的:
- 调查骨质疏松症 (OP) 的患病率,危险因素和病理生理学,在患有脊髓关节病 (SpA) 的患者中.
- 要区分OP和axSpA与PsA之间的关系.
主要方法:
- 在Medline.上进行电子文献搜索.
- 搜索的重点是确定报告有关SPA患者OP患病率,风险因素和病理生理学的研究.
主要成果:
- 全球OP流行率为18.3%. 在 axSpA 中,OP 的患病率在11.7%至34.4%之间.
- 在PsA中,OP的患病率与一般人群的患病率相似.
- 在SPA中OP的危险因素包括皮质类固醇的使用和身体不活动. 系统性炎症,包括TNF和IL-23/IL-17等细胞因子,在骨损失中起作用.
结论:
- 骨质疏松症是axSpA中确定的并发症,炎症可能是导致骨质损失的原因.
- 作为PsA的并发症,OP的作用不太清楚,可能是与治疗相关的不良事件.
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