植物活性物质对类风湿性关节炎的影响 - - 一项系统性审查和网络元分析
Qiuwei Peng1, Jian Wang1, Kesong Li1
1Department of Rheumatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Frontiers in pharmacology
|February 20, 2025
概括
这一网络的元分析表明,植物性化合物如黄素,氨酸和白醇在控制类风湿性关节炎 (RA) 症状方面表现有前途. 需要进一步的研究来证实它们对RA患者的有效性和安全性.
科学领域:
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
- 基于证据的医学是基于证据的医学.
背景情况:
- 植物活性物质广泛用于类风湿性关节炎 (RA) 治疗.
- 现有的证据证明它们的有效性往往是有限的,没有证据.
- 缺乏可靠的数据,需要对这些自然疗法进行严格的评估.
研究的目的:
- 评估植物活性物质对类风湿性关节炎 (RA) 的影响.
- 进行网络元分析 (NMA) 以比较各种植物性治疗方法.
- 为自然化合物的治疗潜力提供基于证据的见解.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Cochrane,Web of Science) 进行系统的文献搜索,直到2024年8月.
- 包括18项研究,涉及1674名RA患者和10种植物活性物质疗法.
- 结果分析包括视觉模拟尺度 (VAS),炎症标志物,胀关节数 (SJC),柔软关节数 (TJC) 和28个关节的疾病活动评分 (DAS28),使用网络元分析和SUCRA排名.
主要成果:
- 奎尔在减少VAS方面表现出最高的疗效 (67.3%).
- 黄素对炎症标志物 (72.3%),SJC (75.6%) 和TJC (76.2%) 最有效.
- 复星对DAS28 (74.3%) 显示出最佳的结果.
结论:
- 与安慰剂相比,黄素显著降低了SJC和TJC.
- 黄素,青素和白醇在治疗 RA 症状方面显示出特殊的益处.
- 虽然有希望,但进一步的研究是必要的,以证实这些植物衍生的疗法对类风湿性关节炎的有效性和安全性.
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