亚洲可以改善老年小鼠的睡眠质量和数量
bioRxiv : the preprint server for biology
|February 20, 2025
概括
亚洲水提取物 (CAW) 在老年小鼠的睡眠改善方面显示出有前途. CAW增加了男性的REM睡眠,减少了女性的睡眠障碍,这表明对睡眠质量有性别相关的影响.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 与年龄相关的睡眠障碍很常见,与认知衰退和神经退行性疾病有关.
- 很少有干预措施有效地逆转与年龄相关的睡眠下降.
- 亚洲的提取物表现出神经保护作用,但它们对睡眠的影响基本上是未知的.
研究的目的:
- 为了研究Centella asiatica水提取物 (CAW) 对老年小鼠睡眠模式的影响.
- 为了确定CAW是否可以减轻与年龄相关的睡眠障碍.
主要方法:
- 年龄较大的雄性和雌性C57BL6/J小鼠 (18个月大) 被食含CAW (1000 mg/kg/天) 或对照食.
- 使用电脑电图 (EEG) 和电脑电图 (EMG) 记录来分析睡眠组成.
主要成果:
- 在老年雄性小鼠中,CAW的使用增加了REM睡眠时间.
- 在老年雌性小鼠中,CAW降低了睡眠期间唤醒的次数.
- 发现CAW对睡眠的影响取决于性别.
结论:
- Centella asiatica水提取物对老年小鼠的睡眠量和质量具有适度的,取决于性别的影响.
- 对于与年龄有关的睡眠障碍,CAW可能是一个潜在的干预措施.
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