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血液线粒体健康标志物cf-mtDNA和GDF15在人类衰老中的作用

Caroline Trumpff¹, Qiuhan Huang¹, Jeremy Michelson¹

¹Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

bioRxiv : the preprint server for biology

|February 20, 2025

概括

增长分化因子15 (GDF15) 是一种可靠的生物标志物,用于衰老和线粒体应激,与无细胞线粒体DNA (cf-mtDNA) 不同. 高等教育可能会影响GDF15水平,这表明心理社会因素会影响线粒体健康.

科学领域:

老年学是一门学科.
生物化学生物化学
分子生物学分子生物学

背景情况:

线粒体功能障碍加速生物衰老,但人口研究的可扩展生物标志物很少.
无细胞线粒体DNA (cf-mtDNA) 和生长分化因子15 (GDF15) 是线粒体健康的潜在生物标志物.
GDF15是一种已确定的衰老生物标志物,与线粒体压力信号相关.

研究的目的:

评估cf-mtDNA和GDF15作为线粒体健康的生物标志物,在一个多样化的成年人群中.
评估cf-mtDNA和GDF15与年龄,BMI,糖尿病,性别和生活方式因素的关联.
探索心理社会因素对线粒体健康标志物的影响.

主要方法:

血和血清cf-mtDNA和血GDF15水平在430名参与者 (24-84岁) 中在基线和5年随访时被测量.
统计分析检查了生物标志物与人口,临床,行为和心理社会变量之间的关联.
在5年期间,生物标志物水平的纵向变化被评估.

主要成果:

GDF15显示出与年龄有很强的正相关性 (指数式),并且在5年内显著增加.
cf-mtDNA水平与GDF15,年龄,BMI或性别没有相关性.
2型糖尿病与更高的GDF15相关;高等教育与较低的年龄调整GDF15相关.

结论:

GDF15是年龄和代谢压力的强大的生物标志物,反映了线粒体的压力信号.
在这种情况下,cf-mtDNA不是衰老或线粒体健康的可靠指标.
心理社会因素,如教育水平,可能会调节GDF15水平,这表明心理社会福祉和线粒体健康之间存在联系.

关键词:

在GDF15中,GDF15是GDF15中的一个.衰老的衰老衰老的衰老 cf-mtDNA DNA 的时间.教育教育教育教育的教育.线粒体的信号传递方式心理社会因素心理社会因素

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