从初级视觉皮层中破坏超视觉电路的破坏影响了两种视觉歧视
C McKinnon1, C Mo2,3, S M Sherman2
1Committee on Computational Neuroscience, University of Chicago, Illinois, USA.
bioRxiv : the preprint server for biology
|February 20, 2025
概括
第5层 (L5) 皮质体回路对于视觉感知至关重要. 在初级视觉皮层中抑制这些电路会损害小鼠视觉区分能力.
科学领域:
- 神经科学是一个神经科学.
- 视觉系统研究 视觉系统研究
- 皮层电路的皮层电路.
背景情况:
- 皮层的第5层 (L5) 向更高层次的乳头核投射,形成跨乳头电路.
- 这些电路与直接的皮质皮质连接平行运行,但它们在感知中的功能尚不清楚.
研究的目的:
- 调查L5-启动的 transthalamic 电路在视觉感知和行为中的作用.
- 确定这些电路对于视觉区分任务的必要性.
主要方法:
- 在小鼠中,有针对性的光遗传抑制从初级视觉皮层 (V1) 到脉动皮层的L5皮质体内输入.
- 鼠标执行了一项视觉区分任务,涉及不同方向的漂移格子.
主要成果:
- 抑制V1 L5跨体内电路显著损害视觉区分性能.
- 行为缺陷在视网膜学上是抑制V1区域的特征.
结论:
- 由L5启动的跨体质回路对于视觉感知和决策至关重要.
- 这些发现强调了 transthalamic 途径在层次感官处理中的重要性.
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