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Updated: May 27, 2025

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
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与帕金森病相关的DNA甲基化和基甲基化在人类大脑中的改变

Juliana I Choza1, Mahek Virani1, Nathan C Kuhn2

  • 1Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ.

bioRxiv : the preprint server for biology
|February 20, 2025
PubMed
概括

这项研究揭示了帕金森病 (PD) 大脑中DNA修饰的显著变化,特别是5-甲基细胞因素 (5-mC) 和5-基甲基细胞因素 (5-hmC). 这些表观遗传变化与参与神经炎症和神经发育的基因有关.

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