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个体差异的多变量神经标记思想控制困难个体差异的多变量神经标记

Jacob DeRosa^1,2, Harry R Smolker², Hyojeong Kim³

¹Department of Psychology and Neuroscience, University of Colorado Boulder.

bioRxiv : the preprint server for biology

|February 20, 2025

概括

控制思想的困难,如反和担忧,与独特的大脑活动模式有关. 在前对对对和默认模式网络中的这些模式可以作为思维控制问题的神经标记.

科学领域:

神经科学是一个神经科学.
认知心理学认知心理学
心理健康研究心理健康研究

背景情况:

难以控制思想,包括反省,担忧和侵入性思想,在各种心理健康障碍中很常见.
了解思想控制的神经基础对于开发有效干预至关重要.

研究的目的:

识别与自我报告的控制思想困难相关的特定大脑活动模式.
调查前端对象和默认模式网络在思维控制缺陷中的作用.

主要方法:

在功能磁共振成像 (fMRI) 数据上利用多变量模式分析.
在四个工作记忆操作期间检查的大脑活动:维护,替换,抑制和清理思维.
与自我报告的思维控制困难相关的神经活动模式.

主要成果:

具有更大的思维控制困难的个体在前对对对和默认模式网络中的任务中显示出更可变和更不差异化的大脑激活模式.
在思想控制问题的人群中,在默认模式网络中观察到较少的明显连接模式.
这些基于任务的神经标记解释了超过30%的思维控制困难的差异.

结论:

在前对对和默认模式网络中,特定的,取决于任务的大脑活动模式与思想控制方面的困难有关.
这些发现表明有希望的神经标记物用于识别和潜在地治疗心理健康障碍中的思维控制缺陷.

关键词:

认知控制认知控制皮层梯度皮层梯度皮层梯度默认模式网络默认模式网络边界对等网络边界对等网络功能连接的功能连接性个人差异个人差异多声素模式分析分析代表性相似性分析工作记忆工作记忆

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